Regioselectivity of Larock Indole Synthesis Using Functionalized Alkynes
نویسندگان
چکیده
منابع مشابه
Regioselectivity of Larock indole synthesis using functionalized alkynes.
Regioselectivity of Larock indole synthesis, a palladium-catalyzed heteroannulation between o-iodoaniline and internal acetylene, was estimated using acetylenes substituted with ester and/or Boc-protected amine at the homopropargylic position and with perbenzyl- and unprotected glucose. Low to moderate regioselectivities were observed in all the cases, indicating these functional groups do not ...
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Several 3,4-disubstituted indole building blocks were synthesized, containing a one-carbon functional group at C-4 and a three-carbon chain bearing at least one functional group. A C-4 functionalized indole derivative was prepared by application of the Leimgruber-Batcho reaction. Several three-carbon chains were subsequently installed at the indole C-3 position. In the first strategy employed, ...
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ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 2008
ISSN: 0916-8451,1347-6947
DOI: 10.1271/bbb.80179